foreword　 　

At present, tumor immunotherapy is in the ascendant, and one of the most effective treatment strategies is adoptive cell transfer therapy (ACT). Chimeric antigen receptor (CAR) and engineered T cell receptor (TCR) are the main adoptive T cell immunotherapy in recent years. TCR engineering T cells express tumor antigen-specific receptors, and their α chains and β chains are produced by high-quality and high-affinity antigen-specific T cell clones.

TCR molecule belongs to a superfamily of immunoglobulin, which consists of two covalently bound polymorphic subunits, each of which is antigen-specific, and they are related to at least four different types of signal transduction chains. In order to activate T cells, there must be interaction between TCR and MHC.

The interaction between TCRs and pMHC(peptide-MHC) determines the fate of immature thymocytes, which is very important for the survival of naive T cells. Therefore, TCR-T immunotherapy technology activates the host’s immune system through effective interaction with MHC, especially class II molecules, which are specifically recognized by TCR-T cells and CAR-T cells. TCR-T cells can recognize tumor-specific antigens in cells, while CAR-T cells mainly recognize tumor-specific antigens on the surface. This makes TCR-T cells more effective in tumor treatment.

At present, some new technologies and tools are being applied to TCR-T, which is helpful to improve the efficacy and safety of TCR-T therapy. TCR-T cell therapy is showing great potential for anti-tumor therapy.

　 Comparison between CAR-T and TCR-T

In ACT therapy, TCR-T and CAR-T cells have been successfully used in the clinical treatment of solid tumors.

CAR contains single chain antibody targeting tumor antigen, transmembrane domain and intracellular activation domain of CD3ζ. In this way, the engineered CAR can recognize specific tumor-associated antigens, and CAR can bind untreated tumor surface antigens without MHC treatment.

The first generation of CAR-T cells showed limited expansion and relatively short persistence, and the "second generation" CAR-T added costimulatory receptors CD28, 4-1BB/CD137 and OX40. These costimulatory receptors are added to the CD3ζ domain of CAR-T cells, thus promoting a more powerful and lasting T cell response. The third generation CARs combines two co-stimulatory signals (CD28 and 4-1BB) at the same time, which has better amplification and longer persistence than the second generation CARs.

On the contrary, TCR is an α/β heterodimer that binds to MHC antigen complex. Compared with TCR, CARs has some disadvantages in identifying tumor antigens, such as extratumoral toxicity. Compared with CARs, TCRs has some structural advantages in T cell-based therapy, such as more subunits (10: 1) in its receptor structure, more tyrosine-based activation motifs (ITAMs) in immune receptors (10: 3), less dependence on antigens (1: 100), and more costimulatory receptors (CD3, CD4, CD28, etc.). TCR with a low MHC affinity range (104-106M-1) can effectively activate T cells, whereas CARs needs a higher affinity range (106-109M-1).

Therefore, CAR-mediated cytotoxicity depends on higher density of cell surface antigens. In addition, T-cell/antigen interaction IS initiated in the structure of immune synapse (IS), in which TCR presents an annular region with peripheral LFA-1 adhesion, while CAR presents a diffuse LFA-1 distribution without annular region. Therefore, TCR-IS is slower but lasts longer than CAR-IS. At the same time, CAR-T cells show faster killing function and migrate to the next tumor target (serial killing), which is in sharp contrast to TCR-T cells’ prolonged signal transduction and killing time.

Recombination TCRs 　

TCR is one of the most complex receptors in human body. It contains six different receptor subunits, which have a very wide range of functions in T cells. The change of TCR of tumor infiltrating lymphocytes (TILs) significantly affects tumor-specific T cells. Among them, the change of TCR is helpful to the proliferation of T cells, and the diversity of TCR is related to the anti-tumor effect.

TCR engineering of TIL is one of the best treatment methods for tumors. TCR consists of α chain and β chain bound to peptide -MHC ligand, signal subunits (,γ and δ) of CD3 complex and CD3ζ homodimer. Except CD3ζ, all subunits have extracellular immunoglobulin (Ig) domain. Based on these structures, new technologies using engineering TCR include ImmTAC, TRuCs and TAC.

Immune mobilization monoclonal t cell receptor (ImmTAC)

ImmTACs is designed using engineered, soluble and affinity-enhanced monoclonal TCRs(mTCRs). ImmTACs is basically a fusion protein, which combines the engineering TCR targeting system and single chain antibody fragment (scFv) effector function. In the construction of ImmTACs, TCR can recognize peptides from intracellular targets presented by human leukocyte antigen (HLA).

ImmTAC specifically targets HLA- peptide complexes on the surface of tumor cells, and promotes T cell-mediated effector function through the interaction between scFv antibody fragments and CD3. ImmTAC also activates CD8+T cells in a dose-dependent manner, and can effectively redirect and activate CD8+ and CD4+ cells. ImmTAC shows multifunctional reaction by secreting various cytokines, such as TNF-α, IFN-γ, IL-6, MIP1α-β and IFN-γ inducible protein 10.

In addition, selecting the appropriate target antigen is the key to ImmTACs, and mass spectrometry and MHC polymer technology are helpful to identify the appropriate antigen. It is worth noting that TCR engineered T cells also show unexpected targeted toxicity. Generally speaking, ImmTACs has been proved to enhance the anti-tumor response of TCR-T cells, but its safety needs further study.

T cell receptor fusion structure

T cell receptor fusion structure (TRuCs), an antibody binding domain fused with T cell receptor subunits, is designed to effectively recognize tumor surface antigens. TRuCs is composed of specific antibodies targeting tumor-associated antigens fused to the extracellular N- terminal of five TCR subunits (TCRα, TCRβ, CD3, CD3γ and CD3δ), which provides new targeting specificity and HLA-independent target cell clearance for engineered T cells and can be activated by corresponding target cells.

Compared with the second generation of CAR-T cells, this method shows better anti-tumor effect. In addition, TRuCs dominates all the signal mechanisms of TCR complex, while CARs only uses the limited signal of the isolated intracellular segment of CD3ζ.

T cell antigen coupling agent (TAC)

T cell antigen coupling agent is another engineered TCR cell, which can induce more effective anti-tumor response and reduce toxicity in an MHC-independent way. TAC chimeric protein can form TCR/CD3 complex and get more T cell responses by binding to CD3 domain.

The activity of TAC receptor is closely related to the selection of CD3 binding domain. For example, a single chain antibody from OKT3(muromonab-CD3) has lower cytokine production and cytotoxicity compared with UCHT1, which may lead to substantially different functional results. Compared with the second generation of CARs, T cells engineered with TAC gene are not only beneficial to the greater infiltration in solid tumors after adoption, but also reduce the expansion and extratumoral toxicity of T cells in healthy tissues expressing antigens.

Workflow of TCR-T cell therapy 　

In order to isolate therapeutic TCR, antigen-specific T cells must be isolated from the blood of patients or healthy blood donors and amplified in vitro with specific peptide antigens and cytokines (such as IL-2 and IL-15). This process needs to determine the specific tumor-related peptide targets that can be safely targeted to patients in advance. After selecting the target antigen, different methods can be used to screen TCR with the required high affinity and tumor specificity. Pre-clinical safety testing is also necessary to ensure the minimum off-target effect and cross-reactivity of isolated high affinity TCR. Viral vectors are usually used to genetically modify autologous patient T cells to express the proven therapeutic TCR, and then transfuse it back into patients.

Determine the target antigen

Melanoma antigen 1(MART-1) recognized by T cells is the first tumor-related antigen targeted in TCR-T clinical trials. After this breakthrough, TCR-T therapies for various tumor antigens have been developed, including TCR-T therapies for MAGE-A3, MAGE-A4, GD2, mesothelin, gp100, MART1, AFP, CEA, NY-ESO-1 and viral peptides derived from HPV and EBV. Among them, NY-ESO-1 has been proved to be one of the most promising targets of TCR-T cells, and it has achieved success in the treatment of synovial sarcoma, with an objective effective rate of 67%.

The ideal TCR-T target antigen shows the following characteristics: (1) the ability to induce immune response; (2) It is related to driving tumor phenotype (such as oncogene) to reduce the risk of antigen loss and tumor immune escape; And (3) expression on tumor stem cells to promote permanent tumor eradication.

Identification method of tumor-associated antigen

High-resolution mass spectrometry (MS) has been proved to be the most powerful Qualcomm method to promote the direct identification of HLA-I binding peptides from tumor cells. In this method, HLA-I/ peptide complexes are separated from tumor tissues or cell lines by immunoprecipitation (IP), and then the binding peptide antigens are separated from HLA-I molecules and antibodies for IP by fully washing and applying acidic elution buffer. This strategy allows each tumor sample to identify thousands of validated peptide targets, and has been used to identify HLA-I ligands of glioblastoma (GB), melanoma, renal cell carcinoma (RCC) and colorectal cancer (CRC).

Identification method of new tumor antigen

Although MS-based technology can be used to identify new antigens, it is more difficult to identify them, especially for tumor samples with limited size, because of their relatively low abundance and limited sensitivity of MS. However, the development of new generation sequencing technology is helpful to identify and locate such tumor targets. All-exon DNA sequencing, combined with computational prediction algorithm, allows to identify specific genetic changes in cancer cells, which can produce mutant peptides and present them on tumor HLA-I molecules.

All somatic mutant genes can be analyzed by computer to predict the potential high affinity epitopes that may bind to HLA-I molecules of patients, so as to be recognized by T cells. With the use of large MS elution peptide database, HLA-I peptide binding prediction algorithm is constantly updated and improved, and other prediction algorithms try to consider biological variables related to the complexity of intracellular processes.

Another commonly used method is tumor RNA sequencing, which allows the selection of new antigens with the highest transcriptional expression. It is worth noting that although these prediction methods usually show very good accuracy in identifying presented and highly immunogenic new antigens, the number of new antigen targets they usually predict is 1 to 2 orders of magnitude higher than the actual number of real targets.

Discovering new antigens by trogocytosis is a new method in recent years. Trogocytosis is a biological phenomenon in the process of cell combination, in which cells share and transfer membrane and membrane-related proteins. Li et al. found that T cell membrane proteins were specifically transferred to tumor target cells, which presented homologous HLA-I/ peptide complexes. Using these T cell-target cell interactions, they created a new antigen discovery system by incubating T cells expressing orphan TCR with homologous target cells. By transferring fluorescent markers from T cells to target cells, this method can isolate these target cells and sequence homologous TCR ligands, thus establishing a new antigen library.

Isolation of tumor-specific T cells and TCR

Using HLA-I polymer, single cell TCR sequencing or antigen-negative humanized mice, tumor-reactive T cells and TCR can be identified from autologous, allogeneic or xenogeneic cell banks.

Using HLA-I multimer method, antigen-specific CD8+T cells can be directly separated by multimer staining and flow cytometry. Before isolating the paired full-length TCR sequences, these polyclonal T cells were tested for homologous peptide recognition and anti-tumor function. TCR with high affinity and specificity can be obtained by using a highly sensitive PCR-based single cell TCR analysis method (TCR-SCAN).

Another method uses humanized mouse TCR gene bank, which will not cause T cell clone deletion or tolerance in humans. Therefore, Li et al. used the whole human TCRα/β gene locus and chimeric HLA-A2 transgene to construct transgenic mice to isolate human TCR against human TAA.

Single cell sequencing method represents a more promising method to isolate tumor-specific TCR coding genes by Qualcomm method. Using RNA bait libraries targeting each individual V and J element in TCRα and TCRβ loci, TCR coding genomic elements can be selectively isolated from excised genomic DNA(gDNA) fragments for subsequent paired terminal deep sequencing. This makes it possible to identify antigen-specific TCR from human materials or oligoclonal T cell populations of TCR humanized mice.

Infantile T cells can also be used as TCR sources for TCR-T therapy. TAA and new antigen-specific T cells can be derived and amplified from low-frequency precursors in peripheral blood of cancer patients, and can be reinfused or used as the source of antigen-specific TCR. Because cancer patients usually show immunosuppression or dominant T cell tolerance, the original sequence of HLA-I matched healthy donors also represents a reliable source, because it has a huge diversity of TCR sequences, and theoretically T cells have any antigen specificity, including new tumor antigens. A Qualcomm-quantity technology platform has been developed to find the original sequence, so as to quickly and effectively identify the rare but valuable TCR for personalized adoptive T cell therapy.

Cloning of TCR

Most TCR-based gene therapy methods rely on in vitro transduction of T cells with viral vectors, and adenovirus is the earliest vector used for gene therapy. However, due to their inability to integrate transgenes into the host genome, TCR expression will be lost during T cell proliferation. In addition, the immune genetic characteristics of adenovirus also limit its application as a gene therapy vector. In contrast, retroviruses show greater prospects as gene transfer vectors, because they can infect a variety of cells and have the ability to insert transgenes into the host genome, thus making the ectopic TCRα/β chain stably expressed.

Retroviral vectors derived from γ -retroviruses such as mouse leukemia virus (MLV) have been widely used for gene transfer into human T cells. This method has been used to transfer various genes, including suicide gene, TCR and CARs. The main disadvantage is that they cannot transduce non-proliferative target cells, which excludes the application of resting T cells in TCR-T therapy. In addition, retrovirus insertion mutation may cause potential side effects.

Recently, lentiviral vectors (LV) have attracted more attention as gene transfer vectors, because they can transfer genes into mitotic and non-splinter cell. Various techniques, such as Golden Gate cloning and LR cloning, are usually used to construct a vector for inserting TCRα/β gene.

Adeno-associated virus (AAV) is another widely used virus vector. Compared with adenovirus vector, AAV has lower immunogenicity and wider cell tropism, so it has been widely used in tumor gene therapy. In order to promote the integration of transgenes, people have developed self-complementary AAV vector (scAAV) to make AAV independent of the complementary strand synthesis of host cells. scAAV is more effective than traditional AAV in preclinical model.

At the same time, some non-viral gene editing methods have also been developed. MRNA electroporation has been proved to achieve transient expression of TCR and CAR, thus minimizing the risk of persistent virus components. Clinical data show that both TCR-T and CAR T cells modified by mRNA are feasible and safe, and there is no obvious evidence that they have non-targeted toxicity to normal tissues. However, the lack of continuous TCR expression may limit the curative effect and require repeated infusion. In addition, the non-viral sleeping beauty retrotransposon system is also used for the transduction of TCR and CARs.

Gene editing can insert large gene fragments into target cells specifically and efficiently through homologous directional repair (HDR). TCR-T cells developed by CRISPR/CAS9 have been proved to specifically recognize tumor antigens in vitro and induce a productive anti-tumor response in vivo.

Verification method of TCR

After TCR cloning, extensive preclinical verification is needed to prove the specificity and safety of engineered TCR-T cells. Verification includes evaluating the affinity of TCR by titration of homologous peptide antigens and measuring the killing effect of a group of HLA-I matched tumor cell lines. If there is no such tumor cell line, the target cells can transductively express related antigens and related HLA-I molecules. The new antigen can also be expressed in autologous antigen presenting cells to evaluate the antigen reactivity of TCR.

The safety test includes testing the ability of candidate TCR-T to identify HLA-I matching primary tissues, so as to ensure that there is no normal tissue as the target, which may lead to non-targeted toxicity. In at least two clinical trials of TCR-T cell therapy, there was a cross reaction between normal brain cells and heart cells, which led to the death of patients. These test results emphasize the importance of extensive safety tests before TCR enters clinical trials.

Safety of TCR-T 　

The ACT of TCR-T cells showed high tumor killing, but some serious adverse events also appeared in some clinical studies. It is very important to optimize TCR affinity in engineered T cells, and receptor affinity can determine the safety and effectiveness of T cell therapy. In terms of curative effect, affinity TCR interaction is enough to activate T cells, but strong affinity is needed to maintain the expansion of T cells.

In phase I/II ACT clinical trials, engineered T cells with low affinity show safer characteristics, but their anti-tumor response is weak. By identifying the TCR-pMHC interaction of T cells, engineered T cells can be divided into high affinity type and low affinity type. In addition, some technologies have been developed to improve the safety of TCR-T.

The safety switch mechanism based on engineered T cells is an attractive strategy. Thymidine kinase gene from herpes simplex virus type I (HSV-TK) is one of the most common suicide genes.

Although HSV-TK shows safety in cell-based immunotherapy, it is necessary to introduce phosphorylated nucleoside analogues. Another safer induced T cell safety switch is called inducible caspase-9(iC9). IC9 is a modified human FK binding protein, which can be activated by a small molecule compound AP1903, and this process depends on the mitochondrial apoptosis pathway.

The immunogenicity of iC9 suicide gene is low, and the immune response to transgenic cells is reduced. IC9-based safety switch has been proved to be more potential for cell therapy than previous suicide genes.

Clinical status of TCR-T cell therapy 　

As of August 9, 2021, there are 175 studies using TCR-T therapy in ClinicalTrials, 71 of which are specific TCR for specific TAA or new antigen, and 32 studies have been completed. NY-ESO-1 is the most common targeted antigen, which is expressed in many cancers, including myeloma and melanoma. Other tumor testis-associated antigens, such as PRAME and MAGE proteins, melanoma differentiation antigens MART-1 and gp100, and recent cancer drivers, such as WT1, KRAS and TP53, are also popular TCR-T targets.　 　 　 　 　 　 　 　 　 　 　

　　　　

A total of 83 sponsors/collaborators initiated or participated in the research of TCR-T cell therapy, including the National Institutes of Health (NIH), government organizations, industries and universities/academic institutions. At present, the National Cancer Institute (NCI) has supported 53 TCR-T projects, accounting for 20% of all ongoing projects.

Among the 29 pharmaceutical companies developing TCR-T therapy, GlaxoSmithKline and Adaptimunime initiated the most clinical trials, with 11 and 7 respectively. Recently, a phase 1 clinical trial (NCT02858310) of TCR-T cells targeting human papillomavirus (HPV)-16 E7 protein in the treatment of metastatic human papillomavirus-related epithelial cancer was reported. In this study, 6 of the 12 patients who received treatment showed objective clinical response and observed steady tumor regression. This is a landmark clinical trial of TCR-T cell therapy, which proves that targeted virus antigen has good clinical effect on patients with virus-related cancer. Other viral antigens explored as TCR targets include HPV-E6 protein, antigens from Epstein-Barr virus (EBV) and human endogenous retrovirus (HERV) targets, such as Herv-E.

MART-1 and NY-ESO-1 TCR-T therapy targeting TAAs also showed clinical efficacy in advanced melanoma, myeloma and non-small cell lung cancer. The total effective rate (ORR) of TCR-T clinical trial is between 0 and 60%. It is worth noting that most of these TCR-T clinical trials only enrolled a small number of patients (2 to 25), so ORR may not be statistically accurate. Therefore, larger-scale phase II and III clinical trials are needed to confirm the actual clinical efficacy of these TCR-T therapies.

Challenges and potential solutions of TCR-T cell therapy 　

Although immunotherapy based on TCR-T cells has shown certain clinical efficacy in most patients receiving treatment, it still faces many challenges in many fields. These challenges include: (1) Immunotoxicity caused by targeting normal tissues; (2) The expression of TCR in engineered T cells is insufficient or transient; (3)T cell exhaustion and dysfunction; (4) tumor immune escape, and (5) most cancer patients lack effective tumor-specific antigens as targets. Overcoming these challenges will be the key to greater clinical success in the future.　 　 　 　 　 　　

　 　 　 　 　 　

Discovery of new targets

At present, the target of peptide antigen for effective and safe immunotherapy of TCR-T is very limited. At present, most of the targets used are TAA. Although it is up-regulated in tumor tissues, it still maintains a low level of expression in normal tissues, which may lead to autoimmune toxicity. Therefore, the new antigen seems to be the safest target for TCR-T cancer treatment. However, the main challenges of developing new antigens in TCR-T clinic include: (1) the mutation of new antigens is individualized to a great extent, and there are differences among cancer patients, so it is difficult to develop widely used immunotherapy products; (2) The expression of new antigens in tumor tissues is often heterogeneous.

Nevertheless, recent reports have highlighted the emergence of new immunogenic antigens widely shared by tumor cells, including mutated KRAS and TP53. Many other studies have also demonstrated the immunogenicity of shared new antigens that can be used to generate potential therapeutic tumor-specific TCR. With the development of next generation sequencing technology, especially single cell DNA sequencing, transcriptome sequencing and mature in vitro verification methods, TCR-T immunotherapy targeting personalized new antigens may become a popular cancer treatment method in the next few years. In addition, the emerging TAA class, such as carcinoembryonic antigen, may also constitute a feasible target for the future development of TCR-T.

Maximize therapeutic TCR expression

The correct pairing of transgenic α and β chains is one of the main challenges that hinder the development of TCR-T cells. Since each transduced T cell includes two endogenous TCR chains and two transformed TCR chains, heterodimers with unknown specificity can lead to potential autoimmune consequences. Another related problem is that improper α/β chain TCR pairing will compete for CD3 complex, thus reducing the surface expression and signal transduction of therapeutic TCR.

There are several methods to properly pair the transduced TCR chains, including: (1) the constant region of partially murine TCR; (2) adding cysteine residues to promote the introduction of disulfide bonds in TCR chains; (3) changing the secondary structure of the constant region of endogenous TCR; (4) adding a signal domain to the intracellular part transduced with TCR; (5) Introducing TCR-α/β chain into substitute effector cells or constructing single-stranded TCR.

Methods to enhance the expression of therapeutic TCR include: (1) codon optimization of TCR-α and TCR-β chain transgene, and (2) changing the configuration of TCR-α/TCR-β vector to optimize expression.

Reduce adverse events

Usually, targeting non-tumor toxicity is the main key obstacle of TAA, and this risk urges researchers to study common new antigens more carefully. At present, several oncogene hot spot mutations are being studied as potential TCR targets, such as phosphoinositide -3- kinase (PI3K), KRAS and TP53. In addition, genetically engineered TCR-T cells with suicide genes are an important safety measure. Obviously, it is very important to develop reliable, identifiable, personalized, highly specific and immunogenic tumor antigen targets to reduce adverse events related to TCR-T cell therapy.

Graft-versus-host disease of allogeneic T cells

Using allogeneic T cells is a very promising scheme, which can overcome manufacturing problems, patient-related immune cell defects and treatment delays. In order to use allogeneic T cells, it is necessary to control graft-versus-host disease caused by transduced allogeneic reactive lymphocytes and rejection of engineered lymphocytes by host immune system.

The deletion of endogenous TCR gene, HLA-I locus or CD52 molecule is one of the strategies to avoid the failure of TCR-T transplantation, which can be achieved by many methods, such as gene editing or using siRNA. In addition, pluripotent stem cell technology is also considered as a potential solution.

　 summarize

In recent years, engineered T cells have shown excellent curative effect in the treatment of hematological tumors. TCR regulation is very important for T cell reactivation, immune response and its clinical effect on foreign antigens. TCR-T cells have incomparable advantages over CAR-T cells, and show great potential in preclinical and clinical research.

However, there are still several key challenges to improve the anti-tumor efficacy of TCR-T immunotherapy, including how to safely increase the affinity of therapeutic TCR, how to identify the common tumor-specific antigen and TCR in the patient population, and how to regulate the expression of TCR and achieve the best function. The solution of these problems will help to give full play to the potential of TCR-T cell therapy and bring hope to cancer patients to relieve their pain.

References:

1.Engineered TCR-T CellI mmunotherapy in Anticancer Precision Medicine: Pros and Cons. Front Immunol.　2021; 12: 658753.

2. Evolution of CD8+　T Cell Receptor(TCR) Engineered Therapies for the Treatment of Cancer. Cells.　2021 Sep; 10(9): 2379.

Intel’s ninth-generation Core has now begun to spread out gradually, and it has launched a comprehensive fight with AMD’s Ruilong.

The performance is quite powerful, but the corresponding power consumption and price are also amazing, soRelatively speaking, many students will pay more attention to the i7-9700K. After all, it is more balanced in terms of specifications, performance and price.

Today, I will bring the test report of the first i7 processor without hyper-threading technology.

Description of product specifications: The appearance of i7-9700K is exactly the same as that of i9-9900K, so I won’t repeat it here. Here is a brief look at the product specifications.

Compared with i9-9900K, the obvious difference is that the core scale has changed from 8 cores and 16 threads to 8 cores and 8 threads, and the hyper-threading technology has been cancelled. In fact, except i9-9900K, all the nine generations of Core have no hyper-threading.

The core frequency drops slightly,The dual-core turbo frequency is 4.9GHz and the full-core turbo frequency is 4.6GHz.

Introduction of test platform:

This time, the motherboard is Huaqing Z390-TAICHI, which is also a product with high attention at present. After careful disassembly, it is found that this product is quite different from Gigabyte Asustek’s design idea, which is very interesting.

The CPU base is still LGA1151, Intel’s ancestral base, which will be used in 2020.

A set of filter capacitors can be seen on the back of the CPU base, and Huaqing also added two additional polymer capacitors to improve the stability of the motherboard current.

The power supply socket of CPU is 8+4PIN, mainly to cope with i9-9900K.

The power supply of CPU is 10+2+2 phases, and heat pipe fins are used to assist heat dissipation, that is to say, the CPU core supplies 10 phases, the centralized display supplies 2 phases and the bus supplies 2 phases.

There is also a R67161PY chip next to the CPU base, which is used to unlock the CPU external frequency adjustment limit from the wiring point of view.

There are still four memory slots, which support dual-channel DDR4.

There are five expansion slots on the motherboard, which are arranged as X1X16NAX1X8NAX4 according to the PCI location, among which the slots of PCI-EX1 are all designed with notches, which can be compatible with high-bandwidth PCI-E expansion cards, such as SATA cards of PCI-E X4.

There are three M.2 SSD expansion slots on the motherboard, all of which can support PCI-E X4 and SATA channels. However, the slots on the left (M2_1) and the right (M2_3) in the figure occupy two SATA interfaces, which are mutually exclusive. The slot in the middle (M2_2) will eat a SATA interface when using the SSD of SATA channel. The M2_3 slot of the motherboard is covered with a metal heat sink.

There is a 24PIN power supply interface and two USB 3.0 front sockets on the side of the motherboard near the memory slot, one of which is horizontal.

The front USB 3.1 Type-C socket can be seen between the memory slot and the SATA interface. The ASM1074 chip next to it is the channel for two USB 3.0 sockets on the motherboard.

The chip of USB Type-C is on the back of the motherboard, and it is an ASM1543. It seems that the mode of chipset direct connection USB 3.1 Type-C used by Huaqing in the past is not very effective, and this time an extra bridge chip is added.

There are 8 SATA interfaces on the motherboard, of which 6 are provided by the chipset natively, 2 are extra bridges, and the bridge chip is ASM1061.

At the bottom of the motherboard is a row of expansion slots. From the chipset side, from right to left, they are SYS FAN, chassis front control pin, BIOS test pin, BIOS cleaning pin, 80 debug lamp, front USB 2.0 and front USB 2.0 (single interface 4PIN). The single-port USB 2.0 pin is a bit strange. This interface is because a USB 2.0 was eaten by wireless Bluetooth, so the general motherboard will not let go directly, because the wires of the chassis are now in groups of two. It’s ok to control the cold headlight group inside the chassis.

Close to the audio system, from right to left in the figure are TPM, SYS FAN, lightning extension pin, RGB 4PIN lamp strip pin *2, digital LED strip pin and front audio pin.

In addition to the two SYS FAN pins at the bottom of the motherboard, the motherboard has three pins between CPU power supply and memory slot, two pins next to PCI-E X1, and one pin between memory slot and M.2 SSD slot. The number of fan pins is still sufficient.

The rear window interfaces of the motherboard are, from the left in the figure, clear COMS button, Wi-Fi antenna interface, USB 3.0*2+PS2, HDMI+DP, USB 3.0*2, USB 3.1*2+LAN, USB 3.1 A+C +LAN, and 3.5 audio *5+ digital fiber.

The main chip of the audio part is ALC1220 of Little Crab, and the power amplification effect of the audio interface in the rear window of the main board is provided by ALC1220 chip. The front audio provides power amplification effect through N5532 chip.

The motherboard adopts dual Gigabit network cards and the mainstream Intel i211+i219 scheme.

The motherboard is integrated with a wireless network card, and the model is Intel’s 3168N.

You can see an ASM1562 chip next to the motherboard chipset, which is two USB 3.1 TYPE-A interfaces corresponding to the motherboard rear window. The three bridge chips behind the SATA interface at the top of the picture are used to switch with the M.2 SSD slot.

The two P13EQX chips in the rear window of the motherboard are used for signal relay of ASM1562 chip and two USB 3.1 TYPE-A interfaces in the rear window of the motherboard.

The ASM1543 on the back of the motherboard provides a bridge for USB 3.1 A+C on the rear window of the motherboard.

There are two L04083B chips at the end of PCI-E X16 slot on the motherboard, which are used to bridge the bandwidth of the graphics card slot to support the 8+8 dual card mode of the graphics card.

Next, the motherboard was disassembled, and the number of armor of Huaqing motherboard was not particularly exaggerated.

The power supply of the motherboard is 10+2+2 phases, the CPU core part is 10 phases, and the centralized display part is 2 phases, both of which share the same scheme. The PWM chip is IR 3520, which is a 6+2-phase control chip, and the DRIVER is extended to 10+2-phase power supply through IR 3598; The input capacitance is 8 solid-state capacitors of Nijikang FP12K, 16V 172 microfarads; MOS adopts one TI 87350D drMOS for each phase, and one MOS can achieve the function of bridge. The inductance is a closed inductor with one inductance R47 per phase; The output capacitors are 10 in the CPU core part and 3 in the display part. The capacitors are all Nijikang FP12K solid-state capacitors with 6.3V 561 microfarads.

The other two items on the motherboard are for the power supply of VCCSA and VCCIO, and the materials used in this part have been reduced. The input capacitance is shared by one Nijikang FP12K solid-state capacitor, with 16V 101 microfarads; MOS is 1 7341EH； per phase; The output capacitor is 1 Nijikang FP12K solid capacitor per phase, 2.5V 821 microfarads.

Memory power supply is a luxury, using 2-phase power supply directly. The PWM chip is UP1674P；; The input capacitance is 2 solid-state capacitors of Nijikang FP12K, 6.3V 561 microfarads; MOS is 87350D drMOS with one TI per phase, which is the same as CPU power supply; The inductance is a closed inductor with one inductance R30 per phase; The output capacitor is 4 solid-state capacitors of Nijikang FP12K, 6.3V 561 microfarads.

There is also a hardware monitoring chip of nuvoTon NCT6791D and a super IO chip of Nuvoton NCT 5567d on the motherboard. The integration level is still a little low.

There is also an ASM1184 chip on the motherboard, which is used to switch PCI-E channels and bridge one PCI-E 3.0 into four PCI-E2.0. Generally speaking, the design ideas of Huaqing and Gigabyte Asustek are quite different. Asustek Gigabyte prefers to use a lot of SWITCH switching and speed reduction to solve the problem of insufficient chipset channels. Huaqing, on the other hand, prefers to use more HUB chips for switching, so as to minimize the loss of PCI-E bandwidth. However, the cost is also obvious. More chips reduce the integration of the motherboard.

Introduction of test platform:

First, introduce the test platform.

The memory is DDR4 8G*4 of the pirate ship. The actual operating frequency is 2666C15.

There will be a test with a unique display in the middle, and the graphics card is the water-cooled version of VEGA 64 by Dylan Hengjin.

SSD is three pieces of Intel, and the system disk uses the mainstream 535 to ensure that the test is closer to the average user. 240G is used as the system disk, and 480G*2 is mainly used to play test games.

　　 The NVMe SSD test used Intel 750 400G.

The radiator is the cool ice god G360RGB.

The power supply is an Antaike HCG-X1000.

The test platform is BC1 of Streacom.

Introduction of performance test items:

For children’s shoes interested in further understanding the comparative performance, detailed test data will be provided here. If you don’t want to see it, you can skip to the last summary.

The test will be roughly divided into the following parts:

-CPU performance test: including system bandwidth, CPU theoretical performance, CPU benchmark test software, CPU rendering test software and 3DMARK physical score.

-Integrated graphics card test: including theoretical performance test, benchmark test software and professional software benchmark of integrated display.

-Matching stand-alone test: including stand-alone benchmark test software, stand-alone game test and stand-alone professional software benchmark.

-Power consumption test: Power consumption is measured under the platform of centralized display and single display.

－ Since this test, WBE3.0 and Android game simulator have been added, and the test items will be more and more abundant.

Performance test and analysis of CPU;

The system bandwidth test shows that the system bandwidth i9-9700K has been further improved, slightly lower than i9-9900K. Compared with i7-8700K, the improvement is mainly concentrated on L1 and L2, especially the bandwidth of L1 is increased by 40%. There is also a 10% improvement in the delay of L1L2.

The theoretical performance test of CPU is carried out with the built-in tools of AIDA64. Excluding memory bandwidth, other computing power is improved by about 40% compared with i7-8700K.

CPU performance test mainly tests some commonly used CPU benchmark software, and also includes some application software and CPU test items in the game. In this part, i7-9700K mainly has advantages in single-threaded testing, and can be close to i9-9900K. However, multithreading performance is relatively general, and some tests are not even as good as i7-8700K.

CPU rendering test, which tests the rendering ability of CPU.

The 3D physical performance test measures the physical scores in the 3DMARK test, which are mainly related to the CPU.

CPU performance test section comparison section:

According to the comprehensive statistics of CPU, i7-9700K and R7 2700X are basically on the same level, but there will be obvious gap with i9-9900K.

In fact, there is still a more tangled problem, that is, single thread and multi-thread, which has also been decomposed here.

-Single thread:Single thread is quite close to i9-9900K, about 5% behind and 5% stronger than i7-8700k.

-multithreading:Multithreading is a relatively weak part, which is about 35% behind I9-9900k, 8% behind R7 2700×8, and stronger than i7-8700K 4%.

Set display performance test:

The theoretical performance test of centralized display is carried out with the built-in tools of AIDA64. Due to the compatibility problem between Intel’s integrated display driver and WIN10 of 1709, i7-9700K did not collect data for integrated display 3D benchmark test, and mainly ran some benchmark test software.

Set display OpenGL benchmark test, and the professional software part is based on SPEC viewperf 12.1.

Set display performance test section:

Since the centralized display of i7-9700K is the same as that of i7-8700K, there is no substantial difference.

With a stand-alone test:

The graphics card is VEGA 64. Simply running i7-9700K is the highest, but the advantage is weak.

Unique 3D game test, i7-9700K will be slightly weaker than i9-9900K in the game test.

In terms of each generation, i7-9700K has a slight advantage over i9-9900K in DX9 & DX11, slightly weaker than i9-9900K in DX11, and has a great advantage in DX12, with the greatest advantage over i9-9900K.

There has always been a big controversy about the resolution in game testing, so I’ll break it down directly here. Because DX11 games account for more than half of my testing, it seems that i7-9700K will be slightly weaker than i9-9900K at both resolutions, but it will be significantly stronger than R7 2700X at 1080P.

OpenGL benchmark test alone. The OpenGL part is based on SPEC viewperf 12.1. This test is a professional operation test for graphics cards, and the gap is more related to CPU single thread.

With a separate test section:

According to the test results, the i7-9700K is quite close to the i9-9900K, which directly throws off other CPUs.

Disk performance test:

The disk test part uses CrystalDiskMark 5,1g data file to run 9 times, which can basically eliminate the test error. The tested SSDs are 535 480G and 750 400G, both of which are hung from the disk. Simply explain the concept in this test, SATA interface and PCI-E channel can be drawn from CPU or chipset (see how CPU manufacturers design). Here, for the sake of unification, all the tests are SATA from chipset and PCI-E from CPU.

Judging from the test results, i7-9700K is roughly equivalent to i9-9900K, and R5 2600X is relatively high in NVMe test mainly because some specific vulnerabilities are not fixed. Please refer to R7 2700X.

Platform power consumption test:

In terms of power consumption, the power consumption control of i7-9700K will be better. In the most extreme case, it is 40W more than i7-87000K, which is within the controllable range.

With the unique display, the overall power consumption of i7-9700K will be between i7-8700K and R5 2600X, which is well controlled.

Detailed statistics:

Summary of test results:

The comparison groups in this test are i9-9900X, R7 2700X, i7-8700K and R5 2600X. All products are close to the current positioning or price of i7-9700K.

Because the performance test environment of CPU has been changing dynamically (system, BIOS, driver), i9-9900K, i7-8700K and R7 2700X have been tested completely. The testing time of R5 2600X is in April 2018.

AMD RYZEN has undergone some changes after updating the BIOS and drivers. The problem of memory copy performance degradation found in the initial test of B450 has been fixed, but at the cost of CPU power consumption increase and NVME disk performance decline. Therefore, it can be confirmed that AMD’s microcode in 1.0.0.4 recently corrected some Spectre vulnerabilities. Overall, the CPU performance is basically unchanged (increased by 0.5%), and the NVMe performance is reduced by 5%. In the release test, the problem of current limiting of R7 2700X baking machine has also been solved, so the power consumption of R7 2700X will be revised and increased by about 15%.

As far as the performance of CPU is concerned, it is quite interesting.After synthesizing various usage scenarios, the i7-9700K and R7 2700X are on a par. Relatively speaking, the single-threaded performance of i7-9700K is more advantageous, while the multi-threaded performance of R7 2700X is more advantageous.

As far as the performance of Jixian is concerned, there is nothing to say because Jixian has not been updated.

With the unique part, the i7-9700K has become the strongest one without any accident, but it has not opened the decisive gap.

In terms of power consumption,I7-9700K is more balanced, a little higher than i7-8700K, and there will be no out-of-control situation like i9-9900K.

Here is a screenshot of the baking machine. i7-9700K can stably bake the FPU project of AIDA 64 in 4.6G.

Finally, the last horizontal comparison table is for your reference.

The performance part only compares the test items related to CPU, and does not include the results of the game performance test. Because the graphics card has been changed in the middle and the memory frequency has changed to some extent, this table can only be used for general reference for the time being. In the table, the results of previous tests (different graphics cards) are not included, and only the test results that are not affected by the graphics card are extracted. In the horizontal test, it is found that R7 2700X is slightly higher than i7-9700K. This is because the benchmark in the previous test is i7-8700K, and the reference benchmark in the horizontal test is i7-7700K all the time, so the CPU with a particularly close performance gap will be affected by the benchmark change, and its ranking will change.

Simple summary:

About CPU performance:

As far as CPU performance is concerned, i7-9700K is quite good by itself. Single-thread performance ensures the fluency of daily software use, and multi-thread performance reaches the level of i7-8700K.

On the performance of centralized display:

The display of i7-9700K has not been updated, so there is no change. With regard to the unique display: In the case of unique display, i7-9700K and i9-9900K are quite close, and they sit firmly in the first group, but relatively speaking, the influence of CPU on game performance is really not great, and there is no substantial difference above six cores.

About power consumption:

The power consumption control of i7-9700K is quite reasonable, even if the FPU is baked alone, it will not roll over. It seems that high frequency+hyper-threading is a poison to AVX instruction set. Accordingly, the B360 motherboard with solid power supply can be considered in the matching of i7-9700K, which can greatly reduce the budget of the whole machine. The motherboard suggests that the power supply of the CPU core should be greater than or equal to 6 phases.

About overclocking:

Because the power consumption control of i7-9700K is much better than that of i9-9900K, it should be easier to achieve super 5G.

Generally speaking, the performance of i7-9700K is relatively excellent, both single-threaded and multi-threaded. However, compared with other products in the market, the biggest embarrassment is that it can’t open the gap with R7 2700X, but there is a big gap in price. The boxed price difference in JD.COM exceeds that in 1000 yuan.

I7-9700K and R7 2700X are just two CPU optimization directions, i7-9700K has advantages in single thread, R7 2700X has advantages in multi-thread, and the two on the other end are also completely qualified, so in the use scenarios of these two CPUs, single-thread performance will be more important. If the price difference between i7-9700K and R7 2700X is below 15%, then i7-9700K will have obvious purchase value.

　　Cctv newsOn the evening of 25th local time, a snowstorm started from southern Wyoming and headed for central Colorado. At present, the snowfall has exceeded 30cm, and the gust speed has reached 72km/h.. Up to now, this winter storm has caused hundreds of flights to be cancelled at Denver International Airport in Colorado, and more than 1,000 passengers stayed overnight at the airport. Another interstate highway was closed due to snowstorm.

　　According to the National Weather Service, the storm will then cross Nebraska and Kansas eastward, bringing 15.2~30.5 cm of snowfall to the areas along the way. At the same time, the National Weather Service also said that another snowstorm, which started on the night of 26th local time, is expected to bring heavy snow to parts of the northwest Pacific coast and reach the snowstorm level in Oregon and northern California. As two snowstorms occurred during Thanksgiving, it is expected to disrupt the plans of tens of millions of Americans to travel during the Thanksgiving holiday. (CCTV reporter Xu Wei)

Nowadays, the first thing for consumers to buy a car is to see whether this car is rich in configuration, and it is no exception to nature. Let’s look down with Xiaobian.

Let’s take a look at Komik’s appearance first. Komuk’s front face looks very clean and refreshing as a whole, and the air intake grille uses a straight waterfall shape, which is very recognizable. Coupled with fashionable headlights, it has a great visual impact. The car is equipped with LED daytime running lights, automatic opening and closing, delayed closing and so on. Coming to the side of the car body, the size of the car body is 4409 mm * 1781 mm * 1606 mm. The car adopts fashionable and dynamic lines, and the side circumference looks very sharp. With large-sized thick-walled tires, the shape is quite simple. In the design of the rear end, the rear end looks very comfortable, the taillights look very simple, and with the unique exhaust pipe, it is very simple and fashionable.

Coming to Komuk, Komuk’s interior looks solid and the visual effect is very good. The car looks very good outside the steering wheel, made of plastic, and looks a little more unique. Let’s take a look at the central control. The design of the center console is reasonable, which makes the interior design quite layered and conforms to the mainstream aesthetics. The dashboard and seats are equally eye-catching, and the car is equipped with a stylish dashboard with excellent display effect. The car adopts imitation leather seats, which are wrapped in place, with exquisite materials and comfortable ride.

Komik is matched with an automatic manual transmission (AT) gearbox, with a maximum power of 80KW and a maximum torque of 141N.m, with good power performance.

The car is equipped with driving mode selection, remote control key, rear wiper, engine start and stop, traction control (ASR/TCS, etc.) and other configurations, which greatly improves the convenience of using the car.

The car introduced today is remarkable in terms of space, configuration and power, and home travel is also a good helper. If you are interested, you might as well experience it.

　　On the afternoon of March 30th, the 2022 excellent network audiovisual works selected by the State Administration of Radio and Television were announced at the 10th China Network Audiovisual Conference. As a comprehensive selection activity for the whole industry, the "National Excellent Network Audio-visual Works Selection Activity" aims to play a leading role in demonstrating excellent network audio-visual works, better meet the new expectations of the people for a better audio-visual life, and gather together the majestic power of struggling for a new era and forging ahead in a new journey.

　　中央广播电视总台央视网共10部作品入选，分别是特别节目《最高领袖与乡村振兴的故事》；网络综艺节目《中央广播电视总台2022网络春晚》；短视频《最高领袖擘画的现代版“富春山居图”》《家风世泽长》《跟着习主席看世界｜最高领袖“典”亮命运共同体》《2021年版清明上河图 藏了一年的彩蛋》《熊猫终极治愈行为大赏》《以梦为马》《好久不见！沉浸式重温70、80、90回不去的童年》;网络直播节目《“中国比利时两国共庆旅比大熊猫双胞胎三岁生日”主题直播》。

特别节目

《最高领袖与乡村振兴的故事》

　　党的二十大召开前夕，乡村振兴战略实施五周年之际，央视网策划推出系列时政微纪录片《最高领袖与乡村振兴的故事》(全5期)，以“山、河、湖、海”作题眼，立足中国版图，围绕最高领袖跨越山海、关心农业农村发展的足迹，展现新时代乡村振兴战略实践成果。尤其《在希望的田野上》一集，采用一镜到底的创意表达，带领观众展开一场穿越之旅，打开振兴之门，看见希望的田野。

Network variety show

CCTV 2022 Network Spring Festival Gala

　　With the theme of "youth is just right, when it is new", the 2022 Internet Spring Festival Evening at the reception desk vividly shows the youthful style and struggle story of the "net-born generation" with the expression of networking and youthfulness, and gathers youthful strength. The party will be broadcast simultaneously through CCTV-1 integrated channel and new media matrix of CCTV, CCTV news, CCTV video, CCTV finance, CCTV literature and art, etc., to achieve cross-circle communication effect.

　　The number of TV viewers reached 143 million, the number of live broadcasts of related content and new media matrix was 150 million, and the number of video broadcasts was 1 billion. It triggered 260 hot topics in the whole network, including 151 hot searches in Weibo.

short video

The modern version of "Fuchun Shan Jutu" painted by the Supreme Leader.

　　General Secretary of the Supreme Leader used the modern version of "Fuchun Shan Jutu" as a metaphor to describe the beautiful vision of rural revitalization in the new era. Based on Fuchun Shan Jutu, CCTV copied and innovated, drew a 6-meter long scroll of traditional Chinese painting, and launched a heavy micro-video, showing the rural butterfly changes under the guidance of the Supreme Leader’s New Era Socialism with Chinese characteristics Thought.

Family style is long.

　　Deze has a long history and a long family tradition. General Secretary of the Supreme Leader emphasized that "family is the first classroom in life, and parents are the first teachers of children". Xi’s family style, adhering to "keeping the family in order" and then "governing the country", comes down in one continuous line and is dedicated to the people. CCTV plans to launch "Family Style and Prosperity" and feel the general secretary’s fiery national conditions.

《跟着习主席看世界｜最高领袖“典”亮命运共同体》

　　2013年，最高领袖主席首次提出人类命运共同体的理念。如今，该理念已成为引领人类文明进步潮流的旗帜。央视网推出微视频，通过VR绘画，带领网友品读习主席阐释命运共同体理念时引用的典故，感悟其中蕴含的中国智慧。

《2021年版清明上河图藏了一年的彩蛋》

　　该片将2021年众多瞬间和元素以彩蛋的形式藏在全图，彩蛋包括人物形象、声音素材、关键物件等，据统计超过200个。彩蛋元素从二次元到三次元，从游戏、动漫、电影、热梗到时政新闻均有涵盖，正如网友评论这是最用心最贴近当代年轻人的一版年终盘点。

《熊猫终极治愈行为大赏》

　　2022年10月27日国际大熊猫日，央视网推出混剪短视频《熊猫终极治愈行为大赏》，记录整合萌宠界各大“顶流”熊猫高萌瞬间，画面更具喜感和萌感，广受海内外网友的喜爱。

《以梦为马》

　　香港回归25周年之际，央视网推出原创动画《以梦为马》，通过举世闻名的“人骑图”和“狮子玉”两匹马从北京南下香港的一路见闻，轻松幽默传播中华传统文化，进而增强文化自信，增进民族认同感。

The miniature scene freeze-frame short film | Long time no see!Immerse yourself in reliving the childhood that you can’t go back to in 70, 80 and 90.

　　The so-called growing up is a journey with no return. In order to welcome the arrival of Children’s Day in 2022, CCTV and the post-1995 miniature landscape creators spent two months recreating the childhood scenes of three generations with a scale of 1:20, and launched a creative miniature scene stop-motion short film "Long time no see! Immerse yourself in reliving the childhood that you can’t go back in 70, 80 and 90.

Webcast program

"China and Belgium celebrate the third birthday of the giant panda twins".

　　On the occasion of the 51st anniversary of the establishment of diplomatic relations between China and Belgium, CCTV Panda Channel, together with many authoritative organizations, launched the world’s first live broadcast of the theme of "China and Belgium celebrate the third birthday of the giant panda twins", and the overseas connection for the celebration of the giant panda’s birthday caused a topical discussion, which set a new high in the live broadcast effect of the overseas account of Panda Channel in 2022. This live link between China and Belgium shows a colorful and vivid image of China, and promotes cultural and cultural exchanges between China and Belgium.

　　Guided by the spirit of the 20th National Congress of the Communist Party of China, CCTV, the General Station of Central Radio and Television, will always take innovation as the main theme, vigorously promote the integrated communication of "thought+art+technology", and strive to create more excellent network audio-visual works with both positive energy and large flow, serving the country’s governance, a better life and economic and social development.

1905 movie network news Directed by Jin Zhencheng and starring Haoran Liu and Chen Douling, the youth suspense film released the finalized poster of "Falling in Love with Another Me" today, officially announcing the finalization on April 19th. At the same time, the role stills of Haoran Liu and Chen Douling also met the audience, and this much-anticipated film finally unveiled its mystery.

"Returning to the age of eighteen", Haoran Liu ushered in the biggest challenge of his film career.

Judging from the posters and role stills released this time, Haoran Liu’s role image is quite different from other works, which is mature, restrained and exudes artistic flavor. In Twins, he is no longer the talented boy who stands behind his brother and sister and is bent on solving the case, but has to face everything that happens around him alone. This was a big challenge for Haoran Liu, who was only eighteen at that time. In order to perform this role well, Haoran Liu devoted himself to the filming process. According to Haoran Liu, he was still immersed in the role for a long time after the filming, so he specially chose to go on vacation to release himself after the filming, which made people wonder what role Haoran Liu would present to everyone.

Since the film, every film that Haoran Liu starred in has had a very good box office performance. With his sunny image and excellent acting skills that are rare among his peers, he has been recognized and loved by the audience step by step. Now, after four years, Twins has finally been released, and the audience can see the 18-year-old Haoran Liu brother again, which is undoubtedly a belated surprise for the domestic youth film market and the audience who love Haoran Liu.

The first screen cooperation, the first encounter between the national school flower and the popular niche

The film Twins tells the story of Li Pin (played by Haoran Liu), an art school student, who got a one-month part-time job by chance. His job was to paint portraits of Tao (Chen Douling), a girl whose birthday is coming soon, so he came to a remote mansion. As a result, two young people who had never met each other became attached, and a youthful encounter began. However, in the process of getting along with each other, Li Pin gradually discovered that there seemed to be some unknown secrets hidden in this house, and the relationship between him and Tao gradually became subtle.

As the outstanding actors of the new generation, the first screen cooperation between Haoran Liu and Chen Douling can be described as very topical. One is a popular young actor who starred in the box office of nearly 5 billion, and his acting skills are first-class; One is a national school flower that stands out from countless competitors. The first film starring in it has achieved good box office results, and their youthful attributes perfectly match the temperament of the film. For the two leading actors, this cooperation is their "first encounter with youth" both inside and outside the play, which is of very special significance. Therefore, when the film has not yet been finalized, countless audiences have expressed their expectations for "Twins". The official announcement of the schedule this time is undoubtedly a reassurance to the audience.

　　[Press conference]

　　The diplomacy of a big country with China characteristics has opened up a new realm

　　— — The heads of relevant departments introduced the diplomatic situation of big countries with China characteristics.

　　Guangming Daily reporter Zhong Chao finishing

　　On the morning of October 20th, the 20th press center of the Party held the fourth press conference. Shen Beili, Vice Minister of the International Liaison Department of the Central Committee, and Ma Zhaoxu, Member of the Party Committee and Vice Minister of the Ministry of Foreign Affairs, introduced the relevant situation around the theme of "The diplomatic thought of the Supreme Leader guides the diplomatic development of a big country with China characteristics" and answered questions from reporters.

　　At Vientiane Station in China-Laos Railway, Laos, the flight attendants of Laozhong Railway Co., Ltd. greeted the passengers outside the "Lancang" EMU. Xinhua news agency

　　The China-Ma Youyi Bridge aided by China connects Malé, the capital of Maldives, with the airport island. Xinhua news agency

　　1. The supreme leader’s diplomatic thought has led us to open up a new diplomatic path for a big country with China characteristics.

　　Ma Zhaoxu:In the decade of the new era, the CPC Central Committee with the Supreme Leader as the core led China’s diplomacy as a big country with characteristics to forge ahead, overcome difficulties and achieve all-round and groundbreaking historical achievements.

　　First, the party’s centralized and unified leadership over foreign work has been comprehensively strengthened. The party’s overall situation and coordination of all parties’ external work have been continuously consolidated. Second, the all-round, multi-level and three-dimensional diplomatic layout is becoming more and more perfect. In the decade of the new era, the total number of countries that have established diplomatic relations has increased from 172 to 181, and the number of partnerships with countries and regional organizations around the world has increased from 41 to 113. Third, national sovereignty, security and development interests have been vigorously safeguarded. We have successively won nine so-called "countries of diplomatic relations" with the Taiwan Province authorities, and the international community’s adherence to the one-China policy has been further consolidated. Fourth, China’s international influence, appeal and shaping power have improved significantly. China’s image as a responsible big country is more deeply rooted in people’s hearts. Fifth, serving the country’s economic and social development is more powerful and effective. Nineteen free trade agreements were signed with 26 countries and regions to promote the entry into force and implementation of the Regional Comprehensive Economic Partnership Agreement.

　　The supreme leader’s diplomatic thought has led us to open up a new diplomatic path for a big country with China characteristics. The leadership of the Party is the foundation and soul of China’s diplomacy, the people are supreme is the source of strength for China’s diplomacy, independence is the fine tradition of China’s diplomacy, and the initial intention of China’s diplomacy is to care about the world. Fairness and justice are the persistence of China’s diplomacy, and courage to struggle is the spiritual character of China’s diplomacy.

　　2. The Party’s external work should be upright, innovative and pioneering.

　　Shen Beili:Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has made a series of important expositions on the Party’s foreign work, which are an important part of the Supreme Leader’s diplomatic thoughts, profoundly answered a series of directional, fundamental and strategic questions about the Party’s foreign work in the new era, raised our Party’s regular understanding of foreign work to a new height, pointed out the direction of progress and injected strong impetus into the Party’s foreign work in the new era.

　　In recent years, the Party’s external work has been innovative and pioneering, holding a high-level dialogue meeting between the Communist Party of China (CPC) and the world’s political parties and a summit meeting between the Communist Party of China (CPC) and the world’s political party leaders, and advocating that political parties from all countries join hands to cope with the unprecedented changes in the world in the past century. We responded to the great concern of political parties in various countries and the international community for our party, and held various briefings and presentations in time after the conclusion of the party’s important meetings. Many foreign political party politicians said that the important meeting in the Communist Party of China (CPC) was "a major event that affects the world and concerns themselves".

　　We have promoted and deepened relations with the ruling parties in socialist countries, political parties in neighboring countries and developing countries, and political parties in developed countries, built various regional and global political party dialogue platforms, constantly consolidated and improved the global political party partnership, and helped deepen and expand the global partnership of equality, openness and cooperation. At present, our party maintains different forms of contact with more than 600 political parties and organizations in the world. We have provided nearly 400 foreign political parties with COVID-19 epidemic prevention, treatment and treatment programs, and provided medical materials and technical assistance to foreign political parties in need. These political parties have said that the Communist Party of China (CPC) was a timely help and "was our true friend".

　　3. Constantly create a new situation in diplomacy of a big country with China characteristics.

　　Ma Zhaoxu:The Party’s Report to the 20th CPC National Congress systematically summed up the historic achievements and changes in the cause of the Party and the state in the new era in the past ten years, scientifically sketched the grand blueprint for building a socialist modern country in an all-round way and promoting the great rejuvenation of the Chinese nation in an all-round way, and held high the banner of promoting world peace and development and building a community of human destiny, which was inspiring and inspiring.

　　The decade in which the supreme leader’s diplomatic thoughts led China’s diplomatic development was a decade in which China achieved a historic leap in its relations with the world and made a historic contribution to the international community. Under the guidance of the supreme leader’s diplomatic thought, we comprehensively promoted the diplomacy of a big country with China characteristics, firmly safeguarded international fairness and justice, promoted the construction of new international relations, actively participated in the reform and construction of the global governance system, won wide international praise, and significantly enhanced China’s international influence, appeal and shaping power.

　　On the new journey, the diplomatic front will unite more closely around the CPC Central Committee with the Supreme Leader as the core, thoroughly study and implement the spirit of the 20th Party Congress, be guided by the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, especially the Supreme Leader’s diplomatic thought, be confident and self-reliant, be upright and innovative, forge ahead courageously, constantly create a new diplomatic situation for a big country with China characteristics, and make new contributions to building a socialist modern country and promoting the great rejuvenation of the Chinese nation in an all-round way.

　　4. The international community pays close attention to the 20th Party Congress.

　　Shen Beili:The 20th National Congress of the Communist Party of China is not only an important event, an important event and a happy event in the political life of our party and country, but also highly concerned and continuously focused by the international community.

　　Political parties, politicians and people from all walks of life in various countries have sent us congratulatory letters, fully expressing their warm congratulations on the victory of the 20 th National Congress of the Communist Party of China.

　　From their congratulatory letters, we can see that they sincerely admire the style of the Supreme Leader General Secretary as a leader of a big party and a big country, and think that the Supreme Leader General Secretary "has keen insight and the spirit of taking responsibility for the times, and has made outstanding contributions to the development of China" and led China to "create the future in a way that benefits all mankind".

　　They earnestly expect the Communist Party of China (CPC) to make greater contributions to the world at a new historical starting point, and believe that the 20th National Congress of the Communist Party of China is "another important milestone in the extraordinary and magnificent historical process of the Communist Party of China (CPC)" and will surely "provide a more solid guarantee for the future development and prosperity of China and the people’s better life". The people of the Communist Party of China (CPC) and China will "continue to make greater contributions to world peace, progress and prosperity".

　　5. China actively participates in international economic cooperation.

　　Ma Zhaoxu:Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has personally promoted the grand diplomacy of the head of state, raised the flag for the diplomacy of a big country with China characteristics, and guided the direction for a chaotic and intertwined world.

　　Not long ago, General Secretary of the Supreme Leader launched a "trip to Central Asia" and attended 31 events intensively within 48 hours, which effectively led China’s relations with relevant countries to a new level.

　　After the outbreak of the COVID-19 epidemic, General Secretary of the Supreme Leader actively carried out "cloud diplomacy", made 181 phone calls with foreign leaders and heads of international organizations, and attended 78 major foreign affairs activities by video, which gathered strong synergy for international anti-epidemic cooperation.

　　The 17th summit of G20 leaders will be held in Bali, Indonesia from November 15th to 16th this year. The G20 is the main forum for international economic cooperation. As an important member of the G20, China has always actively participated in international economic cooperation and global economic governance, and worked with all parties to promote strong, sustainable, balanced and inclusive growth of the world economy.

　　6. Promote the building of a community of human destiny with practical actions.

　　Ma Zhaoxu:The purpose and goal of China’s foreign policy is very clear, that is, to safeguard world peace, promote common development and promote the building of a community of human destiny. At present, changes in the world, times and history are unfolding in an unprecedented way. The historical trend of peace, development, cooperation and win-win is irresistible. At the same time, human society faces many unprecedented challenges. There are indeed some forces in the world who go against the historical trend, cling to the cold war mentality and zero-sum game, are keen to piece together small circles, fight a "new cold war", draw ideological lines, provoke camp confrontation, and engage in hegemony and bullying. This is the greatest threat to the world order. A divided world is not in anyone’s interest, and camp confrontation will only bring the world into a "dead end."

　　China insists on building a community of human destiny through practical actions. Under the personal leadership and promotion of the Supreme Leader General Secretary, substantial progress has been made in building a community of human destiny in all fields and directions from country to region and from bilateral to multilateral. China firmly upholds the international system with the United Nations at the core, the international order based on international law and the basic norms of international relations based on the purposes and principles of the United Nations Charter, and promotes the development of global governance in a more just and rational direction.

　　The global epidemic of COVID-19 and the Ukrainian crisis further demonstrate the true significance of the concept of building a community of human destiny. We will firmly stand on the right side of history, on the side of human civilization and progress, hold high the banner of peace, development, cooperation and win-win, seek our own development while firmly safeguarding world peace and development, and better safeguard world peace and development through our own development.

　　7. Work together to contribute to the development of human civilization.

　　Shen Beili:"Non-interference in each other’s internal affairs" and "mutual learning and mutual learning" are dialectical unity, which embodies our party’s consistent position of respecting the diversity of human political civilization and promoting the progress of human political civilization.

　　"Non-interference in each other’s internal affairs" is the general consensus of political parties in various countries and the basic norm of international relations, and it is the premise for different political parties to maintain their independence. Regardless of the length of history, the number of people, the strength, and whether they are in power or not, political parties should treat each other as equals and respect each other. The choice of political system and development path is a matter for political parties and people of all countries. Our Party will not dictate the internal affairs of political parties in other countries, nor will it "export" the China model and ask other countries and political parties to "copy" our practices. At the same time, we are determined not to accept condescending and bossy preaching, and we will never copy the political system of other countries.

　　"Learning from each other" is an important driving force for the prosperity and development of human political civilization. By other’s faults, wise men correct their own. Promoting the progress of human civilization is inseparable from seeking common ground while reserving differences and learning from each other. Our party has always attached importance to exchanges and dialogues with political parties in other countries, and actively learned from and absorbed all outstanding achievements of human civilization. In the future, our party will continue to carry out in-depth exchanges of experience in governing the country with foreign political parties, jointly strengthen its own construction, enhance its governance capacity, better benefit the people, and work together to contribute to the development of human civilization.

　　[PConline information]Android 5.0 is finally here! After the preview release and the official version of the jump ticket, now Android 5.0 has finally begun to push. Google started pushing Android 5.0 in the early morning of November 12th, US time, and released the system image of Android 5.0. Nexus 5, Nexus 7 2012/2013 WiFi version, Nexus 10 and other devices can all be upgraded to Android 5.0 through system image and OTA, while Nexus 4 can be upgraded through OTA although it does not have a system image of Android 5.0. However, the Nexus 7 LTE version has not been upgraded, and Google may need to debug it, but I believe it will not keep users waiting for too long.

Android 5.0 has started OTA push upgrade.

　　Google released the system image of Android 5.0 on the developer’s website. So far, the system images of Nexus 5, Nexus 7 2012 WiFi version, Nexus 7 2013 WiFi version, Nexus 10, Nexus 9 and Nexus Player have all been released. You can use ADB line brush to brush the system image into the Nexus device to upgrade Android 5.0, but this will clear the data. If you want to keep the original data, you can wait for OTA push. According to the introduction of Google engineers, only 1% of the devices can receive OTA within 24 to 48 hours, and it takes about one week to reach 50%. It will take 2-3 weeks for all devices to receive OTA. Please wait patiently.

Google released the Android 5.0 system image download (Click here to view.)

　　The download address of Android 5.0 system image is as follows:

　　Nexus 9 Wi-Fi “volantis” LRX21Q：Click here to download.

　　Nexus 5 GSM/LTE “hammerhead” LRX21O：Click here to download.

　　Nexus 7 2013 Wi-Fi “razor” LRX21P：Click here to download.

　　Nexus 7 2012 Wi-Fi “nakasi” LRX21P：Click here to download.

　　Nexus 10 “mantaray” LRX21P：Click here to download.

　　Nexus Player “fugu” LRX21M：Click here to download.

　　The Android 5.0 system images of Nexus 4 and Nexus 6 have not yet been released, but if there is no accident, Google will also release the Android 5.0 system images of these two devices in November. In addition, users who can’t wait for OTA push and don’t want to clear the data can wait for the release of OTA packets, which I believe will happen in these two days. Android 5.0 is a revolutionary Android system. Don’t miss this Android 5.0 upgrade for Nexus users!

[Recommended]Download with PConline official client

　

　　According to Voice of China’s Global Chinese Broadcasting Network, I believe that in many cities in China, people may be familiar with such a scene: in residential areas, people take blue buckets to swipe their cards in front of a cabinet water purifier to receive water, or in their own kitchens, they get drinking water through filtering equipment.

　　With the improvement of people’s requirements for drinking water quality, people pay more and more attention to the safety and health of drinking water, and water purifiers have become the "new favorites" of many families and communities. However, there is also a contradiction between water purification and water saving.

　　Mr. Wang, a citizen of Qingdao, bought a household water purifier at the beginning of this year. He can drink pure water by turning on the tap, which makes the family’s life much more convenient. But at the end of the month, when I saw the water meter, Mr. Wang was startled.

　　Mr. Wang: The water fee at home is 20 to 30 yuan. Since this was installed, I think it was basically between 40 and 50 in the first two months, which was basically doubled. Later, I learned after asking that after it produced one cup of water, it would basically produce three to four more cups of wastewater.

　　The water purifier has become a waste water machine, so invisible water waste exists not only in household water purifiers, but also in water purification drinking machines set up in many communities. The reporter learned that in many communities in Qingdao, there are three or four such direct drinking machines for water purification. If you put in a piece of 30 cents, you can receive a small bucket of 7.5 liters of water. Because it is more affordable than buying bottled water, many citizens like this direct drinking machine very much. But in the interview, most citizens said they didn’t know about the water waste caused by the direct drinking machine.

　　Citizen: (I used to think) it is so economical and not wasteful, but I didn’t know it was so wasteful.

　　How much water is wasted by this drinking machine? The staff of the water company calculated an account for the reporter. To put it simply, it takes three buckets of tap water to make such a bucket of pure water. The reporter learned that the lowest wastewater rate of water purifiers is 1: 1, and the highest can reach 1: 4. According to the data released by home appliance research institute Yikang, in 2014, there were about 15 million reverse osmosis water purifiers in use in China, and the average annual water consumption of each household reverse osmosis water purifier was about 30 tons, and that of commercial ones was about 60 tons. Only by measuring the low average wastewater rate of 1: 1: 23, there were about one billion tons of tap water lost in vain every year. Insiders reminded that while enjoying clean water, don’t forget to save water.

　　If you use the reverse osmosis water purifier to produce 1 liter of pure water, 3 to 4 liters of water will flow into the sewer. Many times, these "tail waters" which are cleaner than tap water are wasted. However, in the reality that the situation of water resources in many areas of our country is extremely severe, it seems that water purification and water saving are becoming a pair of contradictions. So is this contradiction simply due to poor water use and insufficient water purification technology? How to achieve a good combination of water saving and water purification? We might as well take a look at some water consumption conditions in overseas countries.

　　As the largest island country in the world, Australia can be called "vast territory and abundant resources". However, due to the dry climate and large evaporation, Australia is a country with relatively short water resources. Hu Fang, an Australian observer of Global Chinese Broadcasting Network, told us that tap water in Australia directly meets the drinking water standard. Therefore, most people drink tap water directly, and do not need secondary purification. Because the water plant directly carries out the water purification treatment, it will save some water compared with the water purification for each camp.

　　Hu Fang: The cold water outlet of tap water in Australia has reached the standard of direct drinking water, so few people install a water purifier at home. Usually, people drink water directly from the tap with cups. For some places with high hygiene requirements, such as hospitals or kindergartens, patients or children are directly allowed to drink tap water. Because it is the direct water purification treatment of the waterworks, in the process of water purification, the waste water is not directly dumped, but repeatedly recycled in the waterworks. Therefore, compared with the fragmented water purifier for each household, it will consume less water resources to filter water again.

　　In addition, Australia’s water resources management is also quite detailed. For example, tap water can be divided into cold water and hot water. Cold water can be drunk directly, and hot water can be used as domestic water, such as bathing and washing vegetables. It is not as pure as cold water and cannot be drunk directly. Treating cold water and hot water differently can make less water need to be purified, which is also a way of saving water.

　　Hu Fang: On the other hand, there will be two outlets of cold water and hot water at the faucet outlet in Australia. Cold water can be directly drunk, while hot water can be used as domestic water, such as bathing and washing vegetables, so the requirements for hot water will not be as pure as cold water. Treat hot water and cold water separately, so that less water needs to be purified, and relatively less water resources are consumed in the process of water purification. In addition, Australia itself is a country that lacks water. In many details, Australians will pay great attention to saving water. For example, in some airports or shopping malls in Australia, the water used for flushing toilets is not tap water that can be directly drunk. Usually, these places will use recycled water for flushing toilets. In addition, many buildings in Australia have a water storage tank in which rainwater after rain will be collected. Usually, the water will be used for flushing the toilet and cleaning the floor, thus further reducing the amount of direct drinking water that needs purification treatment.

　　Tang Xinzi, a Japanese observer of Global Chinese Broadcasting Network, told us that Japanese people’s drinking water also comes directly from tap water. Mineral water and purified water are often emergency items for Japanese people to prepare for disasters. At the same time, Japan’s water resources treatment system is quite transparent to the public.

　　Tang Xinzi: When I returned to China, I found that, including my own home, pure water was delivered to my door in buckets. This phenomenon has never been seen in Japan. Turning on the tap in Japan is basically drinkable water, which is the same in urban and rural areas. There are 35 strict requirements for the standard test of water system management. Children are taken to visit local water purification facilities from the beginning of primary school to learn how to clean drinking water in the community. The whole water purification process is transparent for users to see. Japan first carries out disinfection treatment, then carries out a higher level of water purification treatment to remove impurities, and finally sends it to the tap of every family, and you can drink it when you turn on the tap.

　　In the United States, sometimes the problem of tap water pollution also appears in social news. Water purifiers, net kettle and mineral water are one of the water sources for many families. What is the real situation of American daily drinking water? Xing Sijia, the international news editor of Voice of China, once studied in the United States. She introduced this.

　　Xing Sijia: I once asked Americans in new york and Washington, D.C., whether tap water at home can be directly used for drinking. Most of them said that they believed that drinking tap water directly had no health problems. However, the reality is that most American families will install a water filter under the faucet in the kitchen to further improve the quality of drinking water. In fact, as early as 1974, the United States Congress passed the National Safe Drinking Water Act, which ensured the safety of drinking water through the protection of the whole process from the water source to the faucet. There are currently more than 160,000 public water supply systems in the United States, including public and private companies. According to the report of the US Environmental Protection Agency, according to the different water sources, American water companies can choose appropriate process combinations to deal with pollutants found in raw water. The most common water purification process includes flocculation, precipitation, filtration and disinfection. Some water supply systems also use ion exchange and absorption methods. It is understood that these methods have not caused excessive waste of water resources. In addition, in order to ensure the timely and accurate test results of tap water, the EPA has also established a set of sampling procedures for the water quality of tap water companies. For example, bacteria should be checked once a month or once a quarter according to the size of the water plant. However, even so, tap water in the United States has been exposed to potential safety hazards from time to time. As early as the end of 2009, the new york Times reported that tens of millions of Americans had problems with their drinking water, and 49 million Americans had been drinking dirty water for at least five years, which not only contained bacteria,It also contains dangerous chemicals such as arsenic and uranium. The reason, according to expert analysis, is that the infrastructure of the water supply system in the United States is in disrepair and aging seriously.

　　On April 9, 2024, the national spring tourism promotion activity of "Spring in China" was held in Luoyang, Henan Province. The activity was co-sponsored by the Resource Development Department of the Ministry of Culture and Tourism, the Press Center of the Ministry of Culture and Tourism, the Henan Provincial Department of Culture and Tourism and the Luoyang Municipal People’s Government, and was undertaken by the Luoyang Municipal Bureau of Culture, Radio, Film and Tourism.

　　Go to the Spring Mountain, smoke in the spring, and enjoy the spring scenery in Henan. The products of tourist routes with abundant spring colors have been officially released, and Henan has launched tourist routes for sightseeing, enjoying flowers, enjoying tea, traveling slowly in the countryside and enjoying leisure and health.

　　Come and follow these five routes, take advantage of this spring to "walk in Henan" and "read China" while enjoying the beautiful scenery in spring and savoring the rich culture.

　　Line one

　　Spring mountains and green waters are all interesting, and the secret world is quiet.

　　It’s warm and windy, and the birds are singing. It’s spring and climbing again. Quiet mountains, gurgling streams and lush vegetation. White clouds and blue sky set each other off and become interesting, and the new green in sight is full of warm vitality!

　　Tour route: Xinyang Jigong Mountain-Nanwan Lake-Nanyang Laojie Mountain-Rose Expo Park-Luoyang Laojun Mountain-Baiyun Mountain-Jiaozuo Yuntai Mountain-Xinxiang South Taihang.

　　Line 2

　　It is when wheatgrass is blooming that flowers bloom all the way.

　　There is a letter in the spring breeze, and flowers bloom for a certain period. Spring in Henan is colorful, from south to north, from east to west. Rape flowers, peach blossoms, cherry blossoms, apricot flowers, peony flowers, forsythia flowers and paulownia flowers bloom one after another, full of youthful eyes, romantic and charming, and the air is filled with the fragrance of spring.

　　Flower viewing route: peony flowers in Luoyang parks and scenic spots-rape flowers in Dengzhou, Nanyang-Taohuayuan ecological scenic spot in Xihua, Zhoukou, peach blossoms, magnolia flowers-Gubaidu cherry blossoms in Zhengzhou-10,000 mu ecological pear garden in Ningling, Shangqiu, pear flowers-Baoquan tulip in Xinxiang-Fuxishan apricot flowers in Xinmi-Lushi Forsythia Flower Sea-Lankao Jiao Yulu Memorial Park.

　　Line 3

　　The spring breeze moistens new buds and enjoys green tea.

　　March to April is the best time to pick Xinyang Maojian tea. Making a pot of spring tea, sipping tea, sitting quietly, and incorporating the freshest buds of generate into your own time and life, is quite interesting.

　　Tea tasting route: Xinyang Tea Museum-Hejiazhai Camping Park-Zhouxiao Tongming Intangible Tea House-Nanwan Lake-Jigongshan-Wenxin Tea Culture Garden

　　Line 4

　　Brushing willows on the embankment drunk with spring smoke, swimming slowly in the countryside.

　　Spring is warm and weeping willows are green. Leave the noisy city, measure the stone path with your footsteps, face the breeze and feel the beauty of the countryside. During the tiring journey, you can also choose a comfortable place to stay and fall asleep, which can make the whole trip more relaxed and comfortable.

　　Slow-paced rural route: Tianpu Daiwan, Xinyang-Haotang Village, Pingqiao District-My humble hometown-Sanhe Village, Songxian County-Chongdugou Village, Luanchuan-The secluded landscape of Sanmenxia-A small cave in Jiyuan-Yunshang Courtyard in Jiaozuo-Lingquan Scenic Spot in Hebi-Gaojiatai Village, Shibanyan Town, Linzhou.

　　Line 5

　　When spring comes to the world, everything is relaxing and healthy.

　　In the season when everything is born, health care is at the right time. In Nanyang, strolling through Zhongjing Health Town, you can experience the inheritance of traditional Chinese medicine and the uniqueness of "preventing diseases" in an immersive way. You can also come to Chenjiagou, Jiaozuo, wen county, the holy place of Taiji, and learn a trick and a half to keep fit and cultivate sentiment.

　　Leisure and Recreation Route: Nanyang Zhongjing Health Town-Nanzhao Wuduoshan Health Tourism Resort-Yiyuan Health Valley in Taowan Town, Luanchuan, Luoyang-Chenjiagou Tai Ji Chuan Cultural Tourism Zone in Jiaozuo wen county-Yuntaishan Health Tourism Base in Jiaozuo-Guoliang Health Tourism Base in Huixian County, Xinxiang-Baoquan Tourism Zone in Huixian County.